N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

Base Information

Chemical Name:N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate
CAS No.:302800-20-0
Molecular Formula:C₂₄H₂₉N₃O₂
Molecular Weight:391.513
Hs Code.:

Synonyms:N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

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Chemical Property of N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

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Technology Process of N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

There total 4 articles about N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 302800-19-7
N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl}-N-methyl methyl carbamate

: 302800-20-0
N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

Guidance literature:: With hydrogenchloride; iron; In ethanol; for 0.5h; Heating;
DOI:10.1021/jm000023o

Reference yield:

: 875-51-4
4-Bromo-2-nitroaniline

: 302800-20-0
N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / NaH / tetrahydrofuran / 18 h / Heating

2: 85 percent / NaH / dimethylformamide / 18 h / 20 °C

3: Pd(PPh₃)4; pyrrolidine / 50 °C

4: 0.75 g / Fe; aq. HCl / ethanol / 0.5 h / Heating

With pyrrolidine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Acylation / 2: Methylation / 3: Arylation / 4: Reduction;
DOI:10.1021/jm000023o

Reference yield:

: 302800-18-6
(4-bromo-2-nitro-phenyl)-carbamic acid methyl ester

: 302800-20-0
N-{4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-aminophenyl}-N-methyl methyl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaH / dimethylformamide / 18 h / 20 °C

2: Pd(PPh₃)4; pyrrolidine / 50 °C

3: 0.75 g / Fe; aq. HCl / ethanol / 0.5 h / Heating

With pyrrolidine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; sodium hydride; In ethanol; N,N-dimethyl-formamide; 1: Methylation / 2: Arylation / 3: Reduction;
DOI:10.1021/jm000023o