Technology Process of 2,6-dimethyl-3-(6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3-pyridinyl)-4H-pyran-4-one
There total 8 articles about 2,6-dimethyl-3-(6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3-pyridinyl)-4H-pyran-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
methanol; water; ethyl acetate;
for 4h;
under 1551.49 Torr;
DOI:10.1021/acs.jmedchem.7b01256
- Guidance literature:
-
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; copper(l) iodide / N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere
2: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water; methanol; ethyl acetate / 4 h / 1551.49 Torr
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine;
In
methanol; water; ethyl acetate; N,N-dimethyl-formamide;
1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b01256
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: iron; acetic acid / 2 h / Inert atmosphere; Reflux
2.1: polyphosphoric acid / water; phosphoric acid / 1.5 h / 95 °C / Inert atmosphere
3.1: water; hydrogenchloride / 48 h / 110 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.03 h / 20 °C
4.2: 1 h / 20 °C
5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; copper(l) iodide / N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water; methanol; ethyl acetate / 4 h / 1551.49 Torr
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; water; hydrogen; iron; potassium carbonate; acetic acid; triethylamine; triphenylphosphine;
In
methanol; phosphoric acid; water; ethyl acetate; N,N-dimethyl-formamide;
5.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b01256