Technology Process of hexahydro-8,8-dimethylpentaleno<1,6a-c>pyran-2,5(1H,6H)-dione
There total 1 articles about hexahydro-8,8-dimethylpentaleno<1,6a-c>pyran-2,5(1H,6H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 10 steps
1: 1.) LiNH2, 2.) perchloric acid / 1.) tert-BuOH, THF, liquid ammonia, 2.) CCl2H2, 3 h
2: 84 percent / sodium ethoxide / ethanol / 1.5 h / Ambient temperature
3: 92 percent / p-TsOH / benzene / 24 h / Heating
4: 1.) diisobutylammonium hydride, 2.) NH4Cl / 1.) ether, hexane, -116 deg C, 1 h -> room temperature, 2.) 2.5 h
5: 82 percent / mercuric acetate / 48 h / Ambient temperature
6: 76 percent / decahydronaphthalene / 4 h / 145 °C
7: 100 percent / pyridinium tosylate / H2O; acetone / 4 h / Ambient temperature
8: 90 percent / sodium methoxide / 4 h / Ambient temperature
9: NaOH / tetrahydrofuran; H2O / 2 h / Ambient temperature
10: Collins reagent / CH2Cl2 / 3 h / Ambient temperature
With
sodium hydroxide; perchloric acid; lithium amide; Diisobutylammonium hydride; Collins oxidation agent; mercury(II) diacetate; sodium methylate; sodium ethanolate; pyridinium p-toluenesulfonate; ammonium chloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; decalin; benzene;
DOI:10.1021/ja00388a029
