Nle-Asp(OBzl)-Phe-NH₂ TFA salt

Base Information

• Chemical Name: Nle-Asp(OBzl)-Phe-NH₂ TFA salt
• CAS No.: 107326-87-4
• Molecular Formula: C₂HF₃O₂*C₂₆H₃₄N₄O₅
• Molecular Weight: 596.604
• Mol file: 107326-87-4.mol

Synonyms:Nle-Asp(OBzl)-Phe-NH₂ TFA salt

Chemical Property of Nle-Asp(OBzl)-Phe-NH₂ TFA salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nle-Asp(OBzl)-Phe-NH₂ TFA salt

There total 2 articles about Nle-Asp(OBzl)-Phe-NH₂ TFA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Nle-Asp(OBzl)-Phe-NH2 (65864-24-6) + trifluoroacetic acid (76-05-1) → Nle-Asp(OBzl)-Phe-NH2 TFA salt (107326-87-4)

Guidance literature:

for 0.5h; Ambient temperature;

DOI:10.1016/0223-5234(91)90056-S

Reference yield:

Boc-Nle-Asp(OBzl)-Phe-NH2 (65864-24-6) → Nle-Asp(OBzl)-Phe-NH2 TFA salt (107326-87-4)

Guidance literature:

With trifluoroacetic acid; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm00053a022

Reference yield: 95.0%

Boc-Trp-OH (13139-14-5) + Nle-Asp(OBzl)-Phe-NH2 TFA salt (107326-87-4) → Boc-Trp-Nle-Asp(OBzl)-Phe-NH2 (117903-30-7)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 1 h, 2.) r.t., 48 h;

DOI:10.1021/jm00126a007

upstream raw materials:

Boc-Nle-Asp(OBzl)-Phe-NH₂

trifluoroacetic acid

Downstream raw materials:

(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-naphthalen-1-yl-propionylamino)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Boc-Trp-Nle-Asp(OBzl)-Phe-NH₂

(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-naphthalen-2-yl-propionylamino)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

C₆₇H₈₇N₁₁O₁₄