1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

Base Information

Chemical Name:1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one
CAS No.:864523-75-1
Molecular Formula:C₁₉H₁₉FN₂O₂
Molecular Weight:326.37
Hs Code.:

Synonyms:1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

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Chemical Property of 1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

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Technology Process of 1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

There total 6 articles about 1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 82297-89-0
(4-fluoro-3-methyl)phenylmagnesium bromide

: 680188-98-1
1,3-diethyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid methoxy-methyl-amide

: 864523-75-1
1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

Guidance literature:: In tetrahydrofuran; at 22 ℃; for 3h;
DOI:10.1016/j.bmcl.2003.12.023

Reference yield:

: 23814-14-4
2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid

: 864523-75-1
1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / NaH / dimethylformamide

2: 100 percent / aq. LiOH / tetrahydrofuran / 2 h / 50 °C

3: Et₃N; oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

4: CH₂Cl₂ / 18 h / 0 - 22 °C

5: 77 percent / tetrahydrofuran / 3 h / 22 °C

With lithium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.12.023

Reference yield:

: 14624-86-3
1,3-diethyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid

: 864523-75-1
1,3-diethyl-5-(4-fluoro-3-methyl-benzoyl)-1,3-dihydro-benzoimidazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

2: CH₂Cl₂ / 18 h / 0 - 22 °C

3: 77 percent / tetrahydrofuran / 3 h / 22 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.12.023