(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

Base Information

Chemical Name:(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid
CAS No.:234081-00-6
Molecular Formula:C₂₆H₂₈N₆O₅
Molecular Weight:504.546
Hs Code.:

Synonyms:(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of (2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

There total 6 articles about (2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 234080-99-0
t-butyl (2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionate

: 234081-00-6
(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 234081-73-3
4-{4-(Pyrimidin-2-yl)-piperazin-1-yl}-benzoic acid

: 234081-00-6
(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 27 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

2: 17 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 233283-14-2
ethyl 4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoate

: 234081-00-6
(2S)-benzyloxycarbonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoylamino]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaOH / methanol; tetrahydrofuran; H₂O / 5 h / 40 °C

2: 27 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

3: 17 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060