3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Base Information

• Chemical Name: 3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester
• CAS No.: 917470-40-7
• Molecular Formula: C₃₈H₄₅N₃O₈SSi
• Molecular Weight: 731.942

Synonyms:3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Chemical Property of 3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

There total 1 articles about 3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.2%

(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester (104146-10-3) + O-tert-butyldimethylsilyl-p-methoxybenzohydroxamic acid (208924-67-8) → C38H45N3O8SSi + 3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester (917470-40-7)

Guidance literature:

With sodium hydride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1039/b612475e

Reference yield: 35.6%

3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester (917470-40-7) → N-[6-(4-methoxybenzoyl)-1,8-dioxo-2,2a,4,5,6,8-hexahydro-1H-7-oxa-3-thia-6,8b-diazacyclobuta[a]naphthalen-2-yl]-2-phenylacetamide (917470-41-8) + 3-[hydroxy-(4-methoxybenzoyl)-amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid (917470-42-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1039/b612475e

Reference yield:

3-[tert-butyldimethylsilyloxy-(4-methoxybenzoyl)amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester (917470-40-7) → 3-[hydroxy-(4-methoxybenzoyl)-amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid (917470-42-9)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1039/b612475e

upstream raw materials:

(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

O-tert-butyldimethylsilyl-p-methoxybenzohydroxamic acid

Downstream raw materials:

N-[6-(4-methoxybenzoyl)-1,8-dioxo-2,2a,4,5,6,8-hexahydro-1H-7-oxa-3-thia-6,8b-diazacyclobuta[a]naphthalen-2-yl]-2-phenylacetamide

3-[hydroxy-(4-methoxybenzoyl)-amino]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid

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