2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Base Information

• Chemical Name: 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one
• CAS No.: 1567375-95-4
• Molecular Formula: C₁₈H₁₆BrN₃O₂
• Molecular Weight: 386.248
• Mol file: 1567375-95-4.mol

Synonyms:2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Chemical Property of 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

There total 3 articles about 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-(2-bromoethoxy)benzoyl chloride (51616-10-5) + 9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one (328546-66-3) → 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-95-4)

Guidance literature:

4-(2-bromoethoxy)benzoyl chloride; 9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one; In pyridine; dichloromethane; at 23 ℃; Inert atmosphere;

With methanesulfonic acid; In methanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2014.01.019

Reference yield: 66.0%

→ 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-95-4)

Guidance literature:

With pyridine; In dichloromethane; at 23 ℃;

With methanesulfonic acid; In methanol; for 3h; Reflux;

Reference yield:

4-(2-bromoethoxy)benzoyl chloride (51616-10-5) + 9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one (328546-66-3) → 2-(4-(2-bromoethoxy)phenyl)-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-95-4) + C18H18BrN3O3

Guidance literature:

In pyridine; dichloromethane; at 23 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2014.01.019

upstream raw materials:

4-(2-bromoethoxy)benzoyl chloride

9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one

Downstream raw materials:

[18F]-FTT

5,6-dihydro-2-(4-(2-(methylsulfonyloxy)ethoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one