(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate
CAS No.:1615253-61-6
Molecular Formula:C₂₂H₂₁ClN₄O₃
Molecular Weight:424.887
Hs Code.:

Synonyms:(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

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Technology Process of (S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

There total 5 articles about (S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 2148-56-3
2-chloro-6-aminobenzoic acid

: 2237-30-1
m-cyanoaniline

: 1615253-61-6
(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: L-N-Boc-Ala; 2-chloro-6-aminobenzoic acid; With pyridine; diphenyl hydrogen phosphite; at 45 ℃; for 1h;

m-cyanoaniline; at 55 ℃;

Reference yield:

: 2148-56-3
2-chloro-6-aminobenzoic acid

: 1615253-61-6
(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; diphenyl phosphite / 2 h / 40 °C

2: 50 °C

With pyridine; diphenyl phosphite;
DOI:10.1021/acs.jmedchem.6b00213

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 1615253-61-6
(S)-tert-butyl (1-(5-chloro-3-(3-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; diphenyl phosphite / 2 h / 40 °C

2: 50 °C

With pyridine; diphenyl phosphite;
DOI:10.1021/acs.jmedchem.6b00213