{4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

Base Information

• Chemical Name: {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.
• CAS No.: 1228935-24-7
• Molecular Formula: C₂₇H₂₂N₆O₃
• Molecular Weight: 478.51
• Mol file: 1228935-24-7.mol

Synonyms:{4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

Chemical Property of {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

There total 3 articles about {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetate (1228935-23-6) → {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid. (1228935-24-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 12h;

Reference yield:

(1-methyl-1H-indazol-3-yl)methanol (1578-96-7) → {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid. (1228935-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium t-butanolate / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.2: -50 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 12 h / 40 °C

With methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3-(chloromethyl)-1-methyl-1H-indazole (1578-97-8) → {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid. (1228935-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

1.2: -50 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 12 h / 40 °C

With trifluoroacetic acid; sodium t-butanolate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl {4-[(1-methyl-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetate

(1-methyl-1H-indazol-3-yl)methanol

3-(chloromethyl)-1-methyl-1H-indazole

Downstream raw materials:

6-{2-[2-(2-methoxyethyl)piperidin-1-yl]-2-oxoethyl}-4-[(1-methyl-1H-indazol-3-yl)methyl]-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

6-{2-[(2R)-2-(3,5-dimethylbenzyl)piperidin-1-yl]-2-oxoethyl}-4-((1-methyl-1H-indazol-3-yl)methyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one