Technology Process of 4α,5α-dimethyl-4β-(2''-1'',3''-dithiolan)-3α-(4'-hydroxybutyl)cyclohexanol
There total 6 articles about 4α,5α-dimethyl-4β-(2''-1'',3''-dithiolan)-3α-(4'-hydroxybutyl)cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) hydroquinone; 2.) 2N HCl / 1.) 140 deg C, 14-18 h.; 2.) THF, 30 min.
2: 66 percent / p-TSA / benzene / Heating
3: 67 percent / thallium (III) nitrate trihydrate / tetrahydrofuran; methanol / 0.08 h / 0 °C
4: 92 percent / cuprous bromide-dimethyl sulphide complex / diethyl ether / -78 deg C, 2 h. then room temp.
5: 1.) borane-dimethyl sulphide; 2.) 3N NaOH, H2O2 / 1.) THF, 1 h.; 2.) THF, water
With
hydrogenchloride; sodium hydroxide; copper(I) bromide dimethylsulfide complex; dimethylsulfide borane complex; dihydrogen peroxide; hydroquinone; thallium(III) nitrate;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)88114-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 66 percent / p-TSA / benzene / Heating
2: 67 percent / thallium (III) nitrate trihydrate / tetrahydrofuran; methanol / 0.08 h / 0 °C
3: 92 percent / cuprous bromide-dimethyl sulphide complex / diethyl ether / -78 deg C, 2 h. then room temp.
4: 1.) borane-dimethyl sulphide; 2.) 3N NaOH, H2O2 / 1.) THF, 1 h.; 2.) THF, water
With
sodium hydroxide; copper(I) bromide dimethylsulfide complex; dimethylsulfide borane complex; dihydrogen peroxide; thallium(III) nitrate;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)88114-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 66 percent / p-TSA / benzene / 0.75 h / Heating
2: 66 percent / p-TSA / benzene / Heating
3: 67 percent / thallium (III) nitrate trihydrate / tetrahydrofuran; methanol / 0.08 h / 0 °C
4: 92 percent / cuprous bromide-dimethyl sulphide complex / diethyl ether / -78 deg C, 2 h. then room temp.
5: 1.) borane-dimethyl sulphide; 2.) 3N NaOH, H2O2 / 1.) THF, 1 h.; 2.) THF, water
With
sodium hydroxide; copper(I) bromide dimethylsulfide complex; dimethylsulfide borane complex; dihydrogen peroxide; toluene-4-sulfonic acid; thallium(III) nitrate;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)88114-X
