1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:189307-27-5
Molecular Formula:C₄₀H₅₀N₂O₇Si
Molecular Weight:698.932
Hs Code.:

1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 4 articles about 1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 177569-52-7
5'(R)-C-allyl-3'-O-(tert-butyldimethylsilyl)thymidine

: 189307-27-5
1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With silver trifluoromethanesulfonate; In pyridine; at 50 ℃; for 20h;
DOI:10.1080/07328319808004219

Reference yield:

: 131118-61-1
3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde

: 189307-27-5
1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuCN / 1.) THF, -5 deg C, 15 min, 2.) THF, room temperature, 6 h

2: 85 percent / AgOTf / pyridine / 20 h / 50 °C

With silver trifluoromethanesulfonate; In pyridine;
DOI:10.1080/07328319808004219

Reference yield:

: 40733-26-4
3',5'-O-di(tert-butyldimethylsilyl)thymidine

: 189307-27-5
1-[(2R,4S,5R)-5-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-but-3-enyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 80percent AcOH / 120 h / Ambient temperature

2: 15.9 g / DCC, pyridine, TFA / dimethylsulfoxide / Ambient temperature

3: 1.) CuCN / 1.) THF, -5 deg C, 15 min, 2.) THF, room temperature, 6 h

4: 85 percent / AgOTf / pyridine / 20 h / 50 °C

With pyridine; silver trifluoromethanesulfonate; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In pyridine; dimethyl sulfoxide;
DOI:10.1080/07328319808004219