4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

Base Information

Chemical Name:4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol
CAS No.:726196-75-4
Molecular Formula:C₁₇H₁₄F₃N₃O₃
Molecular Weight:365.312
Hs Code.:

Synonyms:4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

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Chemical Property of 4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

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Technology Process of 4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

There total 6 articles about 4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 726196-69-6
5-(4-(benzyloxy)phenyl)-1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazole

: 726196-75-4
4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

Guidance literature:: With boron trichloride; In dichloromethane; at -20 - 0 ℃; for 4h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/acschemneuro.8b00102

Reference yield:

: 101935-25-5
2-(4-methoxyphenyl)hydrazine-1-carboxamide

: 726196-75-4
4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / toluene / 1 h / 110 °C

2: potassium hydroxide / water; ethanol / 1.6 h / Heating

3: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

4: boron trichloride / dichloromethane / 4 h / -20 - 0 °C / Inert atmosphere

With pyridine; boron trichloride; potassium carbonate; potassium iodide; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acschemneuro.8b00102

Reference yield:

: 726196-76-5
2-(4-(benzyloxy)benzoyl)-2-(4-methoxyphenyl)-hydrazinecarboxamide

: 726196-75-4
4-(1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazol-5-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water; ethanol / 1.6 h / Heating

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3: boron trichloride / dichloromethane / 4 h / -20 - 0 °C / Inert atmosphere

With boron trichloride; potassium carbonate; potassium iodide; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acschemneuro.8b00102