N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

Base Information

Chemical Name:N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine
CAS No.:1246532-95-5
Molecular Formula:C₂₂H₃₀N₈O
Molecular Weight:422.533
Hs Code.:

N<sub>6</sub>-cyclohexyl-N<sub>2</sub>-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

Synonyms:N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

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Chemical Property of N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

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Technology Process of N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

There total 4 articles about N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1246532-97-7
C₃₂H₄₆N₈O₄

: 1246532-95-5
N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

: 39639-45-7
(2-chloro-9H-purin-6-yl)-cyclohexyl-amine

: 1246532-95-5
N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / Reflux

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C

3: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 2: Buchwald coupling;
DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1246532-95-5
N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 °C / Neat (no solvent)

2: palladium 10% on activated carbon; hydrogen / methanol

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C

4: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; toluene; 3: Buchwald coupling;
DOI:10.1016/j.bmcl.2012.04.131