9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Base Information

Chemical Name:9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine
CAS No.:82995-96-8
Molecular Formula:C₂₉H₄₆N₆O₄SSi₂
Molecular Weight:630.959
Hs Code.:

Synonyms:9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Suppliers and Price of 9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

There total 4 articles about 9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 83005-49-6
2-<(methoxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-phenylthiopurine

: 82995-96-8
9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Guidance literature:: With ammonia; In ethanol; Ambient temperature;
DOI:10.1021/jo00144a014

Reference yield:

: 13464-19-2
phenyl chlorothioformate

: 82995-96-8
9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyridine / 5 h / 0 - 20 °C

2: 80 percent / aq. NaOH, Dowex AG-50, pyridinium form / tetrahydrofuran; methanol; H₂O / 0.67 h / 0 °C

3: 77 percent / ammonia / ethanol / Ambient temperature

With pyridine; sodium hydroxide; Dowex AG-50; ammonia; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jo00144a014

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 82995-96-8
9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)-2-ureidopurine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyridine / 5 h / 0 - 20 °C

2: 80 percent / aq. NaOH, Dowex AG-50, pyridinium form / tetrahydrofuran; methanol; H₂O / 0.67 h / 0 °C

3: 77 percent / ammonia / ethanol / Ambient temperature

With pyridine; sodium hydroxide; Dowex AG-50; ammonia; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jo00144a014