methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

Base Information

Chemical Name:methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate
CAS No.:1404436-92-5
Molecular Formula:C₁₈H₁₃F₃INO₃
Molecular Weight:475.206
Hs Code.:

Synonyms:methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

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Chemical Property of methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

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Technology Process of methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

There total 3 articles about methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404436-83-4
methyl 4-(dimethylamino)-2-hydroxy-5-((2-(trifluoromethyl)phenyl)ethynyl)benzoate

: 1404436-92-5
methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

Guidance literature:: With iodine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 27559-59-7
4-dimethylamino-2-hydroxy-benzoic acid methyl ester

: 1404436-92-5
methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; iodine / diethyl ether; water / 6 h / 20 °C

1.2: pH 3

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: iodine / dichloromethane / 4 h / 20 °C

With iodine; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1143579-89-8
methyl 4-(dimethylamino)-2-hydroxy-5-iodobenzoate

: 1404436-92-5
methyl 6-hydroxy-3-iodo-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: iodine / dichloromethane / 4 h / 20 °C

With iodine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;