Technology Process of D-lyxo-Hexonic acid, 6-deoxy-5-C-methyl-4-O-methyl-2,3-O-(1-methylethylidene)-, delta-lactone (9CI)
There total 6 articles about D-lyxo-Hexonic acid, 6-deoxy-5-C-methyl-4-O-methyl-2,3-O-(1-methylethylidene)-, delta-lactone (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 25 ℃;
for 8h;
DOI:10.1021/jo048953t
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -42 °C
1.2: 91 percent / tetrahydrofuran; hexane / -42 - 25 °C
2.1: NaH / tetrahydrofuran / 0.33 h / 25 °C
2.2: 95 percent / tetrahydrofuran / 12 h / 25 °C
3.1: 26 percent / AD-mix-β; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 36 h / 0 °C
4.1: 86 percent / KOBu-t / tetrahydrofuran / 10 h / 25 °C
5.1: 96 percent / H2 / Pd/C / ethyl acetate / 12 h / 25 °C / 760 Torr
6.1: 82 percent / pyridinium chlorochromate / CH2Cl2 / 8 h / 25 °C
With
n-butyllithium; methanesulfonamide; AD-mix-β; potassium tert-butylate; hydrogen; sodium hydride; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo048953t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaH / tetrahydrofuran / 0.33 h / 25 °C
1.2: 95 percent / tetrahydrofuran / 12 h / 25 °C
2.1: 26 percent / AD-mix-β; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 36 h / 0 °C
3.1: 86 percent / KOBu-t / tetrahydrofuran / 10 h / 25 °C
4.1: 96 percent / H2 / Pd/C / ethyl acetate / 12 h / 25 °C / 760 Torr
5.1: 82 percent / pyridinium chlorochromate / CH2Cl2 / 8 h / 25 °C
With
methanesulfonamide; AD-mix-β; potassium tert-butylate; hydrogen; sodium hydride; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo048953t