11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

Base Information

Chemical Name:11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid
CAS No.:144170-17-2
Molecular Formula:C₂₈H₂₉NO₄
Molecular Weight:443.543
Hs Code.:

11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenz<b,e>oxepin-2-carboxylic acid

Synonyms:11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

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Chemical Property of 11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

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Technology Process of 11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

There total 5 articles about 11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 144170-16-1
6,11-Dihydro-N-(2,6-diisopropylphenyl)-2-methoxycarbonyl-dibenz[b,e]oxepin-11-carboxamide

: 144170-17-2
11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 0.0833333h; Heating;
DOI:10.1021/jm00032a014

Reference yield:

: 79669-87-7
methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

: 144170-17-2
11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 10 h / Ambient temperature

2: 9.2 g / BF₃*Et₂O / CH₂Cl₂ / 5 h

3: 9.42 g / KMnO₄ / acetone; 2-methyl-propan-2-ol / 1.5 h / pH 6.86

4: 1.) SOCl₂, 2.) NEt₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂

5: 92 percent / 5N aq.NaOH / methanol / 0.08 h / Heating

With sodium hydroxide; potassium permanganate; thionyl chloride; boron trifluoride diethyl etherate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetone; tert-butyl alcohol;
DOI:10.1021/jm00032a014

Reference yield:

: 144171-00-6
2-(methoxycarbonyl)-6,11-dihydrodibenzoxepin-11-carboxaldehyde

: 144170-17-2
11-<(2,6-diisopropylphenyl)carbamoyl>-6,11-dihydrodibenzoxepin-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 9.42 g / KMnO₄ / acetone; 2-methyl-propan-2-ol / 1.5 h / pH 6.86

2: 1.) SOCl₂, 2.) NEt₃ / 1.) CH₂Cl₂, 2.) CH₂Cl₂

3: 92 percent / 5N aq.NaOH / methanol / 0.08 h / Heating

With sodium hydroxide; potassium permanganate; thionyl chloride; triethylamine; In methanol; acetone; tert-butyl alcohol;
DOI:10.1021/jm00032a014