4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester
• CAS No.: 1210908-09-0
• Molecular Formula: C₁₃H₁₄F₃NO₃
• Molecular Weight: 289.254
• Mol file: 1210908-09-0.mol

Synonyms:4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester

Chemical Property of 4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester

There total 1 articles about 4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2,2,2-trifluoroacetyl)benzoic acid tert-butyl ester (1210908-08-9) → 4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester (1210908-09-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; for 72h; Reflux;

DOI:10.1021/bc900466q

Reference yield: 73.0%

4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester (1210908-09-0) + p-toluenesulfonyl chloride (98-59-9) → 4-(2,2,2-trifluoro-1-((p-tolylsulfonyloxy)imino)ethyl)benzoic acid tert-butyl ester (1210908-11-4)

Guidance literature:

With pyridine; for 72h; Reflux;

DOI:10.1021/bc900466q

Reference yield:

4-(2,2,2-trifluoro-1-(hydroxyimino)ethyl)benzoic acid tert-butyl ester (1210908-09-0) → 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic acid tert-butyl ester (1210908-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetone / 1 h / 0 - 20 °C

2: ammonia / diethyl ether / 4 h / -78 - 80 °C / Sealed tube

With ammonia; triethylamine; In diethyl ether; acetone;

DOI:10.1021/ol503630z

upstream raw materials:

4-(2,2,2-trifluoroacetyl)benzoic acid tert-butyl ester

Downstream raw materials:

4-(2,2,2-trifluoro-1-((p-tolylsulfonyloxy)imino)ethyl)benzoic acid tert-butyl ester

4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic acid tert-butyl ester