(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

Base Information

Chemical Name:(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol
CAS No.:868696-95-1
Molecular Formula:C₂₃H₂₆O₂
Molecular Weight:334.458
Hs Code.:

Synonyms:(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

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Chemical Property of (1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

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Technology Process of (1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

There total 7 articles about (1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 868696-85-9
1-((2R,3R,4R,5S)-2,5-Diphenethyl-4-vinyl-tetrahydro-furan-3-yl)-prop-2-en-1-ol

: 868696-95-1
(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2005.08.046

Reference yield:

: 868696-82-6
(4S,2'R,3'S,4'S,5'S)-4-benzyl-3-(2',5'-diphenethyl-4'-vinyltetrahydrofuran-3'-carbonyl)-oxazolidin-2-one

: 868696-95-1
(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / aq. NaBH₄ / tetrahydrofuran / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: PPh₃ / CH₂Cl₂

3.1: DBU / toluene / 20 °C

4.1: 76 percent / n-BuLi / tetrahydrofuran / 0 - 20 °C

5.1: 81 percent / PCC / CH₂Cl₂ / 20 °C

6.1: 83 percent / tetrahydrofuran / 0 - 20 °C

7.1: 86 percent / (Pcy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; Grubbs catalyst first generation; n-butyllithium; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2005.08.046

Reference yield:

: 868696-94-0
(2R,3S,4R,5S)-2,5-Diphenethyl-4-vinyl-tetrahydro-furan-3-carbaldehyde

: 868696-95-1
(1S,3R,3aR,6aR)-1,3-Diphenethyl-3,3a,4,6a-tetrahydro-1H-cyclopenta[c]furan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / tetrahydrofuran / 0 - 20 °C

2: 86 percent / (Pcy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 °C

With Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.08.046