5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester
CAS No.:73312-14-8
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

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Technology Process of 5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

There total 1 articles about 5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 73312-12-6
4-(4-tert-Butyl-phenyl)-4-cyano-heptanedioic acid dimethyl ester

: 73312-14-8
5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 5h; Heating;
DOI:10.1021/jm00178a014

Reference yield: 78.0%

: 73312-14-8
5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

: 73312-16-0
1-(4-tert-Butyl-phenyl)-4-oxo-cyclohexanecarbonitrile

Guidance literature:: With sulfuric acid; In acetic acid; for 24h; Heating;
DOI:10.1021/jm00178a014

Reference yield:

: 73312-14-8
5-(4-tert-Butyl-phenyl)-5-cyano-2-oxo-cyclohexanecarboxylic acid methyl ester

: 65619-69-4
4-(p-t-butylphenyl)-4-dimethylaminocyclohexanone

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / aq. H₂SO₄ / acetic acid / 24 h / Heating

2: 89 percent / TsOH / benzene / 6 h / Heating

3: 74 percent / NaOH / ethane-1,2-diol / 18 h / Heating

4: 71 percent / Et₃N, (C₆H₅O)2PON₃ / various solvent(s) / 2 h / 90 °C

5: 94 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

6: 2.) NaBH₄ / 1.) H₂O, MeOH, reflux, 4 h, 2.) H₂O, MeOH, RT, 2 h

7: 60 percent / aq. HCl / methanol / 48 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuric acid; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; ethylene glycol; acetic acid; benzene;
DOI:10.1021/jm00178a014