1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

Base Information

Chemical Name:1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide
CAS No.:1382485-87-1
Molecular Formula:C₂₀H₁₉N₅O₂
Molecular Weight:361.403
Hs Code.:

Synonyms:1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

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Chemical Property of 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

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Technology Process of 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

There total 5 articles about 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1382486-37-4
C₁₆H₁₅BrN₂O₂

: 1382485-87-1
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 485828-58-8
1-(4- bromophenyl)cyclobutane-1-carbonitrile

: 1382485-87-1
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 48 h / 110 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: potassium carbonate / tetrahydrofuran / 0.25 h / 20 °C

3.2: 2 h / 60 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1382485-87-1
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-(2-hydroxypyridin-4-yl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 0 - 20 °C

2.1: potassium hydroxide / ethanol / 48 h / 110 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: potassium carbonate / tetrahydrofuran / 0.25 h / 20 °C

4.2: 2 h / 60 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

With sodium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;