2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime

Base Information

• Chemical Name: 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime
• CAS No.: 947771-03-1
• Molecular Formula: C₂₄H₂₅N₃O₄Si
• Molecular Weight: 447.566
• Mol file: 947771-03-1.mol

Synonyms:2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime

Chemical Property of 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime

There total 3 articles about 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde → 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime (947771-03-1)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In methanol; at 20 ℃;

DOI:10.1002/anie.200602050

Reference yield:

{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-methanol (914933-48-5) → 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime (947771-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / 0 °C

2: hydroxylamine hydrochloride; Na₂CO₃ / H₂O; methanol / 1 h / 0 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; sodium carbonate; Dess-Martin periodane; In methanol; dichloromethane; water;

DOI:10.1002/chem.200700033

Reference yield:

2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde → 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime (947771-03-1) + C24H25N3O4Si

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In methanol; water; at 0 ℃; for 1h; Title compound not separated from byproducts.;

DOI:10.1002/chem.200700033

upstream raw materials:

{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-methanol

Downstream raw materials:

C₃₈H₅₀N₂O₉Si

(R)-1-{2-[(S)-(tert-butyldiphenylsilyloxy)oxazol-5-ylmethyl]oxazol-4-yl}-3-[(2R,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl]-3-hydroxypropan-1-one

3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole