O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime

Base Information

• Chemical Name: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime
• CAS No.: 1255738-00-1
• Molecular Formula: C₁₇H₂₄BrN₃O₄S
• Molecular Weight: 446.365
• Mol file: 1255738-00-1.mol

Synonyms:O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime

Chemical Property of O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime

There total 9 articles about O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-N-phenylsulfonylpyrrolidin-2-carboxamidoxime (1255737-92-8) + C6H10BrClO (1254975-35-3) → O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime (1255738-00-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.crci.2009.11.006

Reference yield:

2-(S)-1-benzenesulfonylpyrrolidine-2-carbonitrile (1198399-07-3) → O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime (1255738-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine / chloroform / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere; Cooling with ice

With hydroxylamine hydrochloride; triethylamine; In dichloromethane; chloroform;

DOI:10.1016/j.crci.2009.11.006

Reference yield:

(S)-2-bromo-3-methylpentanoic acid (21582-41-2,32644-17-0,32653-36-4,42880-22-8,94318-70-4) → O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime (1255738-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere; Cooling with ice

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.crci.2009.11.006

upstream raw materials:

(2S)-N-phenylsulfonylpyrrolidin-2-carboxamidoxime

C₆H₁₀BrClO

2-(S)-1-benzenesulfonylpyrrolidine-2-carbonitrile

(S)-2-bromo-3-methylpentanoic acid

Downstream raw materials:

(2'S,5R)-5-sec-butyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one