Cbz-dehydroisoleucine

Base Information

• Chemical Name: Cbz-dehydroisoleucine
• CAS No.: 118609-92-0
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 118609-92-0.mol

Synonyms:Cbz-dehydroisoleucine

Chemical Property of Cbz-dehydroisoleucine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Cbz-dehydroisoleucine

There total 1 articles about Cbz-dehydroisoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-oxo-3(RS)-methylvaleric acid (1460-34-0) + O-benzyl carbamate (621-84-1) → Cbz-dehydroisoleucine (118609-92-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

Reference yield: 66.0%

L-Alanine methyl ester (10065-72-2) + Cbz-dehydroisoleucine (118609-92-0) → (S)-2-((E)-2-Benzyloxycarbonylamino-3-methyl-pent-2-enoylamino)-propionic acid methyl ester

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at -10 ℃;

DOI:10.1246/bcsj.68.3549

Reference yield:

Cbz-dehydroisoleucine (118609-92-0) → (S)-2-((E)-2-Benzyloxycarbonylamino-3-methyl-pent-2-enoylamino)-propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / -10 °C

2: 100 percent / 2-mercaptoethanol, McIlvaine buffer / 24 h / 35 °C / pH: 8.0, papain

With McIlvaine buffer; dicyclohexyl-carbodiimide; 2-hydroxyethanethiol; In dichloromethane;

DOI:10.1246/bcsj.68.3549

upstream raw materials:

2-oxo-3(RS)-methylvaleric acid

O-benzyl carbamate

Refernces