2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

Base Information

Chemical Name:2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine
CAS No.:338969-77-0
Molecular Formula:C₂₅H₄₁N₃Si
Molecular Weight:411.706
Hs Code.:

Synonyms:2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

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Chemical Property of 2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

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Technology Process of 2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

There total 1 articles about 2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4430-75-5,96606-12-1
octahydro-1H-pyrido[1,2-a]pyrazine

: 299432-99-8
6-bromo-1-(triisopropylsilyl)-1H-indole

: 338969-77-0
2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

Guidance literature:: With tri-tert-butyl phosphine; sodium t-butanolate; palladium diacetate; In xylene; at 110 ℃; for 2h;

Reference yield:

: 338969-77-0
2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

: 2-[1-(2,4-difluoro-benzenesulfonyl)-1H-indol-6-yl]-octahydro-pyrido[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran

2: NaHMDS / tetrahydrofuran

With tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; 1: desilylation / 2: sulfonylation;
DOI:10.1016/S0960-894X(00)00320-6

Reference yield:

: 338969-77-0
2-(1-(triisopropylsilyl)-1H-indol-6-yl)-octahydro-1H-pyrido[1,2-a]pyrazine

: 2-(1-benzenesulfonyl-1H-indol-6-yl)-octahydro-pyrido[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran

2: NaHMDS / tetrahydrofuran

With tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; 1: desilylation / 2: sulfonylation;
DOI:10.1016/S0960-894X(00)00320-6