methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

Base Information

Chemical Name:methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate
CAS No.:540524-37-6
Molecular Formula:C₃₅H₃₄ClNO₅S
Molecular Weight:616.178
Hs Code.:

Synonyms:methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

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Chemical Property of methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

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Technology Process of methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

There total 10 articles about methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 916136-76-0
methyl 3-[4-({2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

: 540524-37-6
methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h;

Reference yield:

: 873-38-1
4-chloro-2-bromoaniline

: 540524-37-6
methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Sealed tube; Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: triethylamine / diethyl ether

5.1: caesium carbonate / acetonitrile / 2 h / Reflux

6.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux; Inert atmosphere

7.1: 1,3-bis-(diphenylphosphino)propane; carbon tetrabromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

8.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

9.1: 4-methylmorpholine N-oxide / acetonitrile / 0.08 h / Molecular sieve; Inert atmosphere

9.2: 1.5 h / 40 °C / Inert atmosphere

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 - 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; dimethylsulfide borane complex; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 540522-76-7
2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethanol

: 540524-37-6
methyl 3-[4-({2-[5-chloro-1-(diphenylmethyl)-2-(2-hydroxyethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-bis-(diphenylphosphino)propane; carbon tetrabromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.1: 4-methylmorpholine N-oxide / acetonitrile / 0.08 h / Molecular sieve; Inert atmosphere

3.2: 1.5 h / 40 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 - 20 °C

With carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;