5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

Base Information

Chemical Name:5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid
CAS No.:220481-75-4
Molecular Formula:C₅₈H₉₈N₈O₁₄
Molecular Weight:1131.46
Hs Code.:

5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

Synonyms:5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

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Chemical Property of 5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

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Technology Process of 5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

There total 1 articles about 5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-20-9
terephthaloyl chloride

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 203568-06-3
5-<4,8-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoic ethyl ester

: 220481-74-3
C₅₈H₉₈N₈O₁₄

: 220481-75-4
5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

: 1,1'-terephthaloyl-bis<4,8,11-bis(tert-butoxycarbonyl)-11-pentanoic acid-1,4,8,11-tetraazacyclotetradecane>

Guidance literature:: With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; sodium hydrogencarbonate; Yield given; Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, RT, 30 min, 2.) THF, RT, 4 h;
DOI:10.1021/jm980358u

Reference yield: 66.0%

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 220481-75-4
5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

: 220481-77-6
3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butoxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

Guidance literature:: With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1021/jm980358u

Reference yield:

: 220481-75-4
5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>carbonyl>benzoyl)-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

: 3'-azido-3'-deoxy-5'-O-<5-(1,4,8-trihydrochloride-11-<4-<(4,8,11-trihydrochloride-1,4,8,11-tetraazacyclotetradecanyl)carbonyl>benzoyl>-1,4,8,11-tetraazacyclotetradecanyl)pentanoyl>thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / DMAP, NEt₃, benzotriazol-1-yloxy-tris(pyrrolidino) phosphonium hexafluorophosphate / CH₂Cl₂; dimethylformamide / 8 h / Ambient temperature

2: 97 percent / HCl gas / diethyl ether / 4 h / Ambient temperature

With hydrogenchloride; dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980358u