3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile

Base Information

• Chemical Name: 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile
• CAS No.: 145434-81-7
• Molecular Formula: C₁₅H₉N₅O₂S
• Molecular Weight: 323.335

Synonyms:3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile

Chemical Property of 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile

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Technology Process of 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile

There total 1 articles about 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

bromomalononitrile (1885-22-9) + 5-cyano-4-oxo-6-(4-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine (70638-54-9) → 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile (145434-81-7)

Guidance literature:

With potassium carbonate; In ethanol; water; for 1h; Heating;

Reference yield: 74.0%

3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile (145434-81-7) + orthoformic acid triethyl ester (122-51-0) → 3-ethoxymethyleneamino-7-(4-methoxyphenyl)-5-oxo-5H-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile (145434-88-4)

Guidance literature:

With acetic anhydride; for 2h; Heating;

Reference yield: 69.0%

morpholine (110-91-8,99108-56-2) + 3-amino-5H-7-(4-methoxyphenyl)-5-oxo-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile (145434-81-7) → 6-Amino-2-(4-methoxy-phenyl)-7-morpholin-4-yl-4,8-dioxo-8,9-dihydro-4H-pyrimido[1,2-a]pyrimidine-3-carbonitrile (145434-97-5)

Guidance literature:

In ethanol; for 5h; Heating;

upstream raw materials:

bromomalononitrile

5-cyano-4-oxo-6-(4-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine

Downstream raw materials:

6-Amino-2-(4-methoxy-phenyl)-4,8-dioxo-7-piperidin-1-yl-8,9-dihydro-4H-pyrimido[1,2-a]pyrimidine-3-carbonitrile

6-Amino-2-(4-methoxy-phenyl)-7-morpholin-4-yl-4,8-dioxo-8,9-dihydro-4H-pyrimido[1,2-a]pyrimidine-3-carbonitrile

4,9-dioxo-7-(4-methoxyphenyl)-1H,4H,9H-thiazolo<3,2-a:4,5-d'>dipyrimidine-8-carbonitrile

3-ethoxymethyleneamino-7-(4-methoxyphenyl)-5-oxo-5H-thiazolo<3,2-a>pyrimidine-2,6-dicarbonitrile

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