N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

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Chemical Name:N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide
CAS No.:1201640-18-7
Molecular Formula:C₃₄H₄₅N₅O₅
Molecular Weight:603.762
Hs Code.:

N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

Synonyms:N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

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Chemical Property of N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

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Technology Process of N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

There total 15 articles about N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201641-37-3
N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1,4-dimethyl-1H-imidazol-2-yl)phenethoxy)propanamide

: 8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

: 1201640-18-7
N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

Guidance literature:: N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(1,4-dimethyl-1H-imidazol-2-yl)phenethoxy)propanamide; With toluene-4-sulfonic acid; In dichloromethane; for 1h;

8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride; With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; for 0.333333h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; for 16h;

Reference yield:

: 871101-87-0
1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone

: 1201640-18-7
N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

1.2: 20 h / 100 °C

2.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 2 h

4.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

5.1: toluene-4-sulfonic acid / dichloromethane / 1 h

5.2: 0.33 h

5.3: 16 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; toluene-4-sulfonic acid; acetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1035229-31-2
1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone

: 1201640-18-7
N-cyclohexyl-3-(3-(1,2-dimethyl-1H-imidazol-2-yl)phenethoxy)-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; zinc / 20 - 40 °C / Cooling with ice

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

2.2: 20 h / 100 °C

3.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

4.1: sodium azide / N,N-dimethyl-formamide / 2 h

5.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

6.1: toluene-4-sulfonic acid / dichloromethane / 1 h

6.2: 0.33 h

6.3: 16 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; toluene-4-sulfonic acid; acetic acid; zinc; palladium 10% on activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;