4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

Base Information

Chemical Name:4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid
CAS No.:118715-10-9
Molecular Formula:C₂₅H₃₄O₆Si
Molecular Weight:458.627
Hs Code.:

Synonyms:4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

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Chemical Property of 4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

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Technology Process of 4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

There total 4 articles about 4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 120927-75-5
N-<2,3-O-isopropylidene-5-O-methyl-4-O-(tert-butyldiphenylsilyl)-D-ribonyl>indole

: 118715-10-9
4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; for 3.5h; Heating;
DOI:10.1021/jo00275a015

Reference yield:

: 71671-16-4
2,3-O-isopropylidene-5-O-methyl-D-ribono-1,4-lactone

: 118715-10-9
4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₂AlCl / 1.) CH₂Cl₂, hexane, RT, 15 min, 2.) CH₂CL₂, phosphate buffer 2.5 h

2: imidazole, 4-(dimethylamino)pyridine / dimethylformamide / 40 h

3: 1.) ozone, 2.) Me₂S, oxalic acid / 1.) CH₂Cl₂, -78 deg C, 2.) reflux, 48 h

4: 81 percent / LiOH, H₂O / tetrahydrofuran / 3.5 h / Heating

With 1H-imidazole; dmap; lithium hydroxide; dimethylsulfide; water; dimethylaluminum chloride; oxalic acid; ozone; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a015

Reference yield:

: 120927-74-4
2-(2-propenyl)-1-(2,3-O-isopropylidene-5-O-methyl-D-ribone)anilide

: 118715-10-9
4-O-(tert-Butyldiphenylsilyl)-2,3-O-isopropylidene-5-O-methyl-D-ribonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole, 4-(dimethylamino)pyridine / dimethylformamide / 40 h

2: 1.) ozone, 2.) Me₂S, oxalic acid / 1.) CH₂Cl₂, -78 deg C, 2.) reflux, 48 h

3: 81 percent / LiOH, H₂O / tetrahydrofuran / 3.5 h / Heating

With 1H-imidazole; dmap; lithium hydroxide; dimethylsulfide; water; oxalic acid; ozone; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a015