dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate

Base Information

• Chemical Name: dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate
• CAS No.: 375379-62-7
• Molecular Formula: C₃₃H₃₁NO₄
• Molecular Weight: 508.59
• Mol file: 375379-62-7.mol

Synonyms:dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate

Chemical Property of dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate

There total 1 articles about dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

iodomethane-d3 (865-50-9) + dimethyl L-N-benzyl-N-(9-phenylfluoren-9-yl)aspartate (146512-92-7) → dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methylaspartate (375379-62-7)

Guidance literature:

dimethyl L-N-benzyl-N-(9-phenylfluoren-9-yl)aspartate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -23 ℃; for 0.166667h;

iodomethane-d3; In tetrahydrofuran; at -23 ℃; for 1h;

DOI:10.1016/S0040-4020(01)00820-1

Reference yield: 36.0%

dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methylaspartate (375379-62-7) → dimethyl (2S,3S)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methylaspartate (375379-63-8)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -23 - 0 ℃;

DOI:10.1016/S0040-4020(01)00820-1

Reference yield: 35.0%

dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methylaspartate (375379-62-7) → dimethyl (2S,3S)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methyl-[3-2H]aspartate + dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H3]methyl-[3-2H]aspartate

Guidance literature:

dimethyl (2S,3R)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate; With potassium hexamethylsilazane; In tetrahydrofuran; at -23 ℃; for 0.25h;

With water-d2; at -23 - 20 ℃;

DOI:10.1016/S0040-4020(01)00820-1

upstream raw materials:

iodomethane-d3

dimethyl L-N-benzyl-N-(9-phenylfluoren-9-yl)aspartate

Downstream raw materials:

dimethyl (2S,3S)-N-benzyl-N-(9-phenylfluoren-9-yl)-3-[2H₃]methylaspartate