(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

Base Information

Chemical Name:(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine
CAS No.:1416133-60-2
Molecular Formula:C₄₂H₄₉F₃N₅O₉P
Molecular Weight:855.848
Hs Code.:

Synonyms:(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

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Chemical Property of (2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

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Technology Process of (2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

There total 4 articles about (2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1416133-59-9
(2'R)-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1416133-60-2
(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2ob26712h

Reference yield:

: C₂₉H₂₆N₂O₅

: 1416133-60-2
(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 12 h / Reflux; Inert atmosphere

2.1: acetic acid / water / 24 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

3.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1039/c2ob26712h

Reference yield:

: 1416133-57-7
C₃₁H₂₆Cl₃N₃O₅

: 1416133-60-2
(2'R)-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamidothymidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water / 24 h / 20 °C

1.2: 1.5 h / 0 - 20 °C

2.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1039/c2ob26712h