C₃₄H₄₉N₅O₁₀

Base Information

• Chemical Name: C₃₄H₄₉N₅O₁₀
• CAS No.: 1309782-07-7
• Molecular Formula: C₃₄H₄₉N₅O₁₀
• Molecular Weight: 687.791
• Mol file: 1309782-07-7.mol

Synonyms:C₃₄H₄₉N₅O₁₀

Chemical Property of C₃₄H₄₉N₅O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₄₉N₅O₁₀

There total 11 articles about C₃₄H₄₉N₅O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C48H61N5O10 (1309782-11-3) → C34H49N5O10 (1309782-07-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.01.084

Reference yield:

(2S)-2-(benzyloxycarbonylamino)-6-(N-(benzyloxy)formamido) hexanoic acid (1007123-38-7) → C34H49N5O10 (1309782-07-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; toluene / 1 h

1.2: 16.5 h / 20 - 110 °C

2.1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

3.1: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

With dmap; 1-hydroxy-7-aza-benzotriazole; 2,4,6-trichlorobenzoyl chloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; 1.1: Yamaguchi reaction / 1.2: Yamaguchi reaction;

DOI:10.1016/j.bmcl.2011.01.084

Reference yield:

C45H60N4O9 (1309782-10-2) → C34H49N5O10 (1309782-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

2: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

With dmap; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2011.01.084

upstream raw materials:

(2S)-2-(benzyloxycarbonylamino)-6-(N-(benzyloxy)formamido) hexanoic acid

C₄₅H₆₀N₄O₉

C₄₈H₆₁N₅O₁₀

C₂₃H₃₆N₂O₄