N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide

Base Information

• Chemical Name: N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide
• CAS No.: 668988-31-6
• Molecular Formula: C₂₆H₂₄N₂O₄
• Molecular Weight: 428.488
• Mol file: 668988-31-6.mol

Synonyms:N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide

Chemical Property of N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide

There total 2 articles about N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-((1-phenoxycarbonyloxy-2-methylpropan-2-ylcarbamoyl)-1-phenylmethyl)-N-phenylbenzamide (668988-24-7) → N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide (668988-31-6)

Guidance literature:

With 4 A molecular sieve; potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at 0 ℃; for 0.166667h;

DOI:10.1055/s-2003-43355

Reference yield:

4,4-dimethyl-2-oxazoline (30093-99-3) → N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide (668988-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 49.7 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 89 percent / methanol / 1 h / 70 °C

3.1: 86 percent / 4 Angstroem molecular sieves; t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.17 h / 0 °C

With n-butyllithium; 4 A molecular sieve; potassium tert-butylate; In tetrahydrofuran; methanol; hexane; tert-butyl alcohol; 2.1: Ugi four-component condensation;

DOI:10.1055/s-2003-43355

Reference yield: 68.0%

N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide (668988-31-6) + 1-dodecylthiol (112-55-0) → S-1-dodecyl 2-(N-phenylbenzamido)-2-phenylethanethioate

Guidance literature:

1-dodecylthiol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.0833333h;

N-((4,4-dimethyl-2-oxo-3-oxazolidinyl)carbonyl-1-phenylmethyl)-N-phenylbenzamide; In tetrahydrofuran; hexane; at 0 ℃; for 0.166667h;

DOI:10.1055/s-2003-43355

upstream raw materials:

N-((1-phenoxycarbonyloxy-2-methylpropan-2-ylcarbamoyl)-1-phenylmethyl)-N-phenylbenzamide

4,4-dimethyl-2-oxazoline