1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

Base Information

Chemical Name:1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone
CAS No.:1313739-70-6
Molecular Formula:C₁₉H₁₉IN₂O₃S
Molecular Weight:482.342
Hs Code.:

Synonyms:1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

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Technology Process of 1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

There total 4 articles about 1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1313739-68-2
N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamine

: 78-95-5
chloroacetone

: 1313739-70-6
1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2.5h; Reflux;
DOI:10.1039/c1ob05087g

Reference yield:

: C₁₆H₁₃IN₂O₂S

: 1313739-70-6
1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / Reflux

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1039/c1ob05087g

Reference yield:

: 176327-46-1
N-(benzenesulfonyl)-3-iodoindole-2-carboxaldehyde

: 1313739-70-6
1-{N-[(3-iodo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-N-methylamino}-2-propanone

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol; dichloromethane / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.5 h / Reflux

With sodium tetrahydroborate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1039/c1ob05087g