(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester
CAS No.:131041-12-8
Molecular Formula:C₂₄H₂₈ClNO₃
Molecular Weight:413.944
Hs Code.:

Synonyms:(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

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Chemical Property of (R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

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Technology Process of (R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

There total 3 articles about (R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52999-73-2
2-(2-chlorophenyl)-2-phenylacetaldehyde

: (R)-1-(2-Bromoethyl)-3-piperidinecarboxylic acid ethyl ester hydrobromide

: 131029-31-7
Z-(R)-1-[2-[[2-(2-Chlorophenyl)-2-phenylethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

: 131041-12-8
(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: 2-(2-chlorophenyl)-2-phenylacetaldehyde; With sodium hydride; In toluene; at 20 ℃; for 0.5h;

(R)-1-(2-Bromoethyl)-3-piperidinecarboxylic acid ethyl ester hydrobromide; In toluene; for 1h;
DOI:10.1021/jm981027k

Reference yield:

: 127586-62-3
(R)-1-(2-hydroxyethyl)-3-piperidinecarboxylic acid ethyl ester

: 131041-12-8
(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / SOBr₂ / toluene / 2 h / 20 °C

2.1: NaH / toluene / 0.5 h / 20 °C

2.2: toluene / 1 h

With sulfurous dibromide; sodium hydride; In toluene; 1.1: Bromination / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1021/jm981027k

Reference yield:

: 37675-19-7
(R)-ethyl piperidine-3-carboxylate hydrochloride

: 131041-12-8
(R)-1-{2-[(E)-2-(2-Chloro-phenyl)-2-phenyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / K₂CO₃; KI / acetone / 18 h / 20 °C

2.1: 68 percent / SOBr₂ / toluene / 2 h / 20 °C

3.1: NaH / toluene / 0.5 h / 20 °C

3.2: toluene / 1 h

With sulfurous dibromide; sodium hydride; potassium carbonate; potassium iodide; In acetone; toluene; 1.1: Alkylation / 2.1: Bromination / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1021/jm981027k