tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate

Base Information

• Chemical Name: tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate
• CAS No.: 1057720-46-3
• Molecular Formula: C₁₄H₁₅BrFNO₂
• Molecular Weight: 328.181
• Mol file: 1057720-46-3.mol

Synonyms:tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate

Chemical Property of tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate

There total 2 articles about tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

propargyl bromide (106-96-7) + (2-bromo-4-fluoro-phenyl)-carbamic acid tert-butyl ester (384793-18-4) → tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate (1057720-46-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1016/j.jfluchem.2007.09.003

Reference yield:

N-(tert-butoxycarbonyl)-4-fluoroaniline (60144-53-8) → tert-butyl N-(2-bromo-4-fluorophenyl)-N-(prop-2-ynyl)carbamate (1057720-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: sodium hydride / N,N-dimethyl-formamide

With n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2015.08.019

upstream raw materials:

propargyl bromide

(2-bromo-4-fluoro-phenyl)-carbamic acid tert-butyl ester

N-(tert-butoxycarbonyl)-4-fluoroaniline