dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

Base Information

Chemical Name:dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate
CAS No.:1620139-20-9
Molecular Formula:C₃₉H₂₉ClN₄O₅S
Molecular Weight:701.202
Hs Code.:

Synonyms:dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

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Technology Process of dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

There total 4 articles about dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 15014-25-2
malonic acid dibenzyl ester

: 1428541-97-2
C₂₂H₁₃ClN₄OS

: 1620139-20-9
dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.05.073

Reference yield:

: 2148-57-4
4,7-dichloroquinazoline

: 1620139-20-9
dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: toluene; ethanol

3: dichloromethane / 20 °C

With potassium carbonate; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2014.05.073

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1620139-20-9
dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: toluene; ethanol

3: dichloromethane / 20 °C

With potassium carbonate; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2014.05.073