6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)

Base Information

Chemical Name:6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)
CAS No.:79390-93-5
Molecular Formula:C₇H₁₀F₂O₃
Molecular Weight:180.151
Hs Code.:

Synonyms:6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)

Suppliers and Price of 6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI)

There total 1 articles about 6-Oxabicyclo[3.1.0]hexane-2-ethanol,4,4-difluoro-3-hydroxy-,[1R-(1-alpha-,2-bta-,3-bta-,5-alpha-)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 73313-50-5,73347-05-4,73365-08-9
(1aS,1bR,4aR,5aS)-5,5-Difluoro-hexahydro-1,4-dioxa-cyclopropa[a]pentalen-3-one

: 73313-51-6,79390-93-5,79390-94-6
(1S,3R,4S,5S)-2,2-Difluoro-4-(2-hydroxy-ethyl)-6-oxa-bicyclo[3.1.0]hexan-3-ol

Guidance literature:: With lithium aluminium tetrahydride; at -40 ℃; for 3h;
DOI:10.1021/jm00177a003

Reference yield:

: 73313-51-6,79390-93-5,79390-94-6
(1S,3R,4S,5S)-2,2-Difluoro-4-(2-hydroxy-ethyl)-6-oxa-bicyclo[3.1.0]hexan-3-ol

: 73313-59-4,73347-11-2
10,10-difluoro-13-dehydroprostacyclin methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / toluene; hexane / 3 h / 55 °C

2: 75 percent / O₂ / Pt / acetone; H₂O

3: 91 percent / i-Bu₂AlH / hexane; toluene / -70 °C

4: 77 percent / 1 h / 25 °C

5: diethyl ether; methanol

6: 81 percent / I₂, NaHCO₃ / diethyl ether / 3.5 h / 0 °C

7: 78 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / toluene / 0.5 h / 90 °C

With iodine; oxygen; diisobutylaluminium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; platinum; In methanol; diethyl ether; hexane; water; acetone; toluene;
DOI:10.1021/jm00177a003