6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

Base Information

Chemical Name:6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine
CAS No.:249757-41-3
Molecular Formula:C₄₃H₅₁ClN₄O₆Si
Molecular Weight:783.44
Hs Code.:

Synonyms:6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

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Chemical Property of 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

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Technology Process of 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

There total 5 articles about 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 79-22-1
methyl chloroformate

: 249757-28-6
6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-8-(triisopropylsilyl)purine

: 249757-41-3
6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

Guidance literature:: With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -70 ℃; for 0.0833333h;
DOI:10.1021/jo9906577

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 249757-41-3
6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / HMPA; LHMDS / tetrahydrofuran / 0.08 h / -70 °C

2: 46 percent / LTMP / tetrahydrofuran / 0.08 h / -70 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethylpiperidinyl-lithium; lithium hexamethyldisilazane; In tetrahydrofuran; 1: Substitution / 2: Condensation;
DOI:10.1021/jo9906577

Reference yield:

: 76-83-5
trityl chloride

: 249757-41-3
6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-2-(methoxycarbonyl)-8-(triisopropylsilyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 20 h / Heating

2: 99 percent / HMPA; LHMDS / tetrahydrofuran / 0.08 h / -70 °C

3: 46 percent / LTMP / tetrahydrofuran / 0.08 h / -70 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethylpiperidinyl-lithium; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Condensation;
DOI:10.1021/jo9906577