3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

Base Information

Chemical Name:3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin
CAS No.:554430-37-4
Molecular Formula:C₃₄H₅₃BrO₈Si₃
Molecular Weight:753.951
Hs Code.:

Synonyms:3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

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Chemical Property of 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

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Technology Process of 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

There total 13 articles about 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554430-36-3
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin

: 554430-37-4
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -10 ℃; for 0.25h;

3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin; In tetrahydrofuran; hexane; at -10 ℃; for 2.5h;

With bromine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

Reference yield:

: 554430-36-3
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin

: 109-72-8,29786-93-4
n-butyllithium

: 554430-37-4
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

Guidance literature:: With IPr₂NH; bromine; sodium hydrogencarbonate; sodium sulfate; In tetrahydrofuran; hexane;

Reference yield:

: 554430-36-3
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin

: 554430-37-4
3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin

: C₃₄H₅₃BrO₈Si₃

Guidance literature:: 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h;

With bromine; at -76 ℃; Reagent/catalyst; Concentration;
DOI:10.1021/op050242p