3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

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Chemical Name:3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide
CAS No.:1415124-56-9
Molecular Formula:C₂₀H₁₅Cl₃N₄O₃
Molecular Weight:465.723
Hs Code.:

Synonyms:3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

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Chemical Property of 3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

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Technology Process of 3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

There total 16 articles about 3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.13%

: 1415125-37-9
2,6-dichloro-4-(methylcarbamoyl)benzoic acid

: 1415125-02-8
N-(3-chloro-1H-pyrrolo [3,2-c]pyridin-4-yl)cyclopropane carboxamide

: 1415124-56-9
3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

Guidance literature:: 2,6-dichloro-4-(methylcarbamoyl)benzoic acid; With dmap; 1-hydroxy-7-aza-benzotriazole; HATU;

N-(3-chloro-1H-pyrrolo [3,2-c]pyridin-4-yl)cyclopropane carboxamide; With N-ethyl-N,N-diisopropylamine; at 20 ℃;

Reference yield:

: 264272-64-2
2,6-dichlorobenzene-1,4-dicarboxylic acid,1-methyl ester

: 1415124-56-9
3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: pyridine; lithium iodide / 3 h / Reflux

3.1: dmap; 1-hydroxy-7-aza-benzotriazole; HATU

3.2: 20 °C

With pyridine; dmap; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; HATU; lithium iodide; In dichloromethane;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1415124-56-9
3,5-dichloro-4-({3-chloro-4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuryl dichloride / diethyl ether / 15 h / 0 - 20 °C

2.1: sulfuric acid; sodium nitrite; acetic acid; phosphinic acid

3.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

4.1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C

4.2: 1 h / 0 - 20 °C

5.1: pyridine; lithium iodide / 3 h / Reflux

6.1: dmap; 1-hydroxy-7-aza-benzotriazole; HATU

6.2: 20 °C

With pyridine; dmap; phosphinic acid; sulfuryl dichloride; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; sulfuric acid; water; acetic acid; HATU; sodium hydroxide; lithium iodide; sodium nitrite; In tetrahydrofuran; diethyl ether; dichloromethane;