5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

Base Information

Chemical Name:5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide
CAS No.:1354721-88-2
Molecular Formula:C₁₆H₉ClF₃N₅O₃
Molecular Weight:411.727
Hs Code.:

Synonyms:5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

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Chemical Property of 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

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Technology Process of 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

There total 3 articles about 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 502686-01-3
5-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine

: 41994-44-9
5-chloro-2-nitrobenzoyl chloride

: 1354721-88-2
5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

Guidance literature:: 5-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine; With sodium hydride; In tetrahydrofuran; mineral oil;

5-chloro-2-nitrobenzoyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 2557-13-3
3-trifluoromethylbenzoic acid methyl ester

: 1354721-88-2
5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 0 °C

1.2: 0 - 75 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil

2.2: 2 h / 20 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 1354721-88-2
5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / 75 °C

2.1: sodium methylate / methanol / 0 °C

2.2: 0 - 75 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil

3.2: 2 h / 20 °C

With thionyl chloride; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; mineral oil;