5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol

Base Information

• Chemical Name: 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol
• CAS No.: 1023327-93-6
• Molecular Formula: C₁₇H₁₃Cl₂FN₄O₂
• Molecular Weight: 395.22

Synonyms:5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol

Chemical Property of 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol

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Technology Process of 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol

There total 1 articles about 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(2-methoxypyrimidin-5-yl)-pyridin-2-amine (1023327-92-5) → 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol (1023327-93-6)

Guidance literature:

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(2-methoxypyrimidin-5-yl)-pyridin-2-amine; With hydrogenchloride; water; In 1,4-dioxane; at 90 ℃; for 3h;

With water; sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃;

Reference yield: 22.0%

(S)-5-bromo-2-tert-butoxycarbonylamino-pentanoic acid cyclopentyl ester (914382-76-6) + 5-{6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-pyrimidin-2-ol (1023327-93-6) → cyclopentyl 5-(5-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)-pyridin-3-yl)-2-oxo-pyrimidin-1-yl)-N-tert-butoxycarbonyl-L-norvalinate (1023327-95-8) + cyclopentyl 5-(5-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-pyrimidin-2-yloxy)-N-tert-butoxycarbonyl-L-norvalinate (1023327-94-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 2h;

upstream raw materials:

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(2-methoxypyrimidin-5-yl)-pyridin-2-amine

Downstream raw materials:

cyclopentyl 5-(5-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)-pyridin-3-yl)-2-oxo-pyrimidin-1-yl)-N-tert-butoxycarbonyl-L-norvalinate

cyclopentyl 5-(5-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-pyrimidin-2-yloxy)-N-tert-butoxycarbonyl-L-norvalinate

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