1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

Base Information

Chemical Name:1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol
CAS No.:149508-96-3
Molecular Formula:C₁₅H₂₀F₃N₃OSi
Molecular Weight:343.424
Hs Code.:

Synonyms:1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

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Chemical Property of 1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

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Technology Process of 1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

There total 3 articles about 1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 95727-88-1
2-(1H-1,2,4-triazol-1-yl)-1-(4-trifluoromethylphenyl)ethanone

: 149508-96-3
1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

Guidance literature:: 2-(1H-1,2,4-triazol-1-yl)-1-(4-trifluoromethylphenyl)ethanone; With magnesium bromide ethyl etherate; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

(trimethylsilyl)methylmagnesium chloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(02)00302-4

Reference yield: 8.0%

: 149508-96-3
1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

Guidance literature:

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 149508-96-3
1-(1H-1,2,4-Triazol-1-yl)-2-(4-trifluoromethylphenyl)-3-trimethylsilyl-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃ / acetonitrile / 5 h / 20 °C

2: 8 percent / diethyl ether / 6 h / Heating

With potassium carbonate; In diethyl ether; acetonitrile; 2: Grignard reaction;
DOI:10.1248/cpb.48.1148