2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE

Base Information

• Chemical Name: 2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE
• CAS No.: 127625-85-8
• Molecular Formula: C₁₄H₁₄ClNO₂S
• Molecular Weight: 295.79
• Mol file: 127625-85-8.mol

Synonyms:2-(4-chlorobutyl)-2H-naphth<1,8-cd>isothiazole 1,1-dioxide

Chemical Property of 2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE

Chemical Property:

• Melting Point: 38 °C

Purity/Quality:

2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE 95.00% ^*data from reagent suppliers

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Technology Process of 2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE

There total 1 articles about 2-(4-CHLOROBUTYL)-1LAMBDA6-NAPHTHO[1,8-CD]ISOTHIAZOLE-1,1(2H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobutyl bromide (6940-78-9) + 1,8-naphthosultam (603-72-5) → 2-(4-chlorobutyl)-2H-naphth<1,8-cd>isothiazole 1,1-dioxide (127625-85-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 25 deg C, 1 h, 2.) DMF, RT, 15 h;

DOI:10.1021/jm00112a025

Reference yield: 41.0%

2-(4-chlorobutyl)-2H-naphth<1,8-cd>isothiazole 1,1-dioxide (127625-85-8) + 1-(4-Fluorophenyl)piperazine (2252-63-3) → 2-<4-<4-(4-fluorophenyl)-1-piperazinyl>butyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide (134133-65-6)

Guidance literature:

With triethylamine; In toluene; 1.) reflux, 8 h, 2.) RT, 15 h;

DOI:10.1021/jm00112a025

Reference yield: 18.0%

1,2,3,6-tetrahydro-4-phenylpyridine (10338-69-9) + 2-(4-chlorobutyl)-2H-naphth<1,8-cd>isothiazole 1,1-dioxide (127625-85-8) → 2-<4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide (127625-43-8)

Guidance literature:

With triethylamine; In toluene; 1.) reflux, 8 h, 2.) RT, 15 h;

DOI:10.1021/jm00112a025

upstream raw materials:

4-chlorobutyl bromide

1,8-naphthosultam

Downstream raw materials:

2-<4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide

2-<4-<4-(4-fluorophenyl)-1-piperazinyl>butyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide

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