C₅₂H₆₂N₅O₁₆PSi

Base Information

• Chemical Name: C₅₂H₆₂N₅O₁₆PSi
• CAS No.: 1004306-97-1
• Molecular Formula: C₅₂H₆₂N₅O₁₆PSi
• Molecular Weight: 1072.15
• Mol file: 1004306-97-1.mol

Synonyms:C₅₂H₆₂N₅O₁₆PSi

Chemical Property of C₅₂H₆₂N₅O₁₆PSi

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₅₂H₆₂N₅O₁₆PSi

There total 1 articles about C₅₂H₆₂N₅O₁₆PSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(1R,3R,4R,7S)-7-(t-butyldimethylsilyloxy)-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1004306-96-0) + (1R,3R,4R,7S)-3-(thymine-1-yl)-1-(4,4′-dimethoxytrityloxy)-7-(2-cyanoethoxy(diisopropylamino)phosphinoxymethyl)-2,5-dioxabicyclo[2.2.1]heptane (206055-75-6) → C49H59N4O16PSi + C52H62N5O16PSi (1004306-97-1)

Guidance literature:

(1R,3R,4R,7S)-7-(t-butyldimethylsilyloxy)-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane; (1R,3R,4R,7S)-3-(thymine-1-yl)-1-(4,4′-dimethoxytrityloxy)-7-(2-cyanoethoxy(diisopropylamino)phosphinoxymethyl)-2,5-dioxabicyclo[2.2.1]heptane; With 1H-tetrazole; In acetonitrile; at 20 ℃; for 2h;

With pyridine; water; iodine; In acetonitrile; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/ja077095q

Reference yield:

C52H62N5O16PSi (1004306-97-1) → C49H59N4O16PSi

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1021/ja077095q

upstream raw materials:

(1R,3R,4R,7S)-7-(t-butyldimethylsilyloxy)-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

(1R,3R,4R,7S)-3-(thymine-1-yl)-1-(4,4′-dimethoxytrityloxy)-7-(2-cyanoethoxy(diisopropylamino)phosphinoxymethyl)-2,5-dioxabicyclo[2.2.1]heptane