1-BENZYL D-ASPARTATE

Base Information

• Chemical Name: 1-BENZYL D-ASPARTATE
• CAS No.: 79337-40-9
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.229
• Hs Code.: 2922509090
• Mol file: 79337-40-9.mol

Synonyms:1-BENZYL D-ASPARTATE;D-Aspartic Acid 1-Benzyl Ester

Chemical Property of 1-BENZYL D-ASPARTATE

Chemical Property:

• Vapor Pressure: 8.17E-07mmHg at 25°C
• Melting Point: 176 °C
• Refractive Index: 14 ° (C=1, 0.1mol/L HCl)
• Boiling Point: 391oC at 760 mmHg
• PKA: 3.45±0.19(Predicted)
• Flash Point: 190.3oC
• PSA: 89.62000
• Density: 1.283g/cm3
• LogP: 1.23210

Purity/Quality:

≥98%,≥99%, ^*data from raw suppliers

H-D-ASP-OBZL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL D-ASPARTATE

There total 2 articles about 1-BENZYL D-ASPARTATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester (92828-64-3) → D-aspartic acid benzyl ester (79337-40-9)

Guidance literature:

With water; at 170 ℃; for 0.05h; Microwave irradiation;

DOI:10.1016/j.tetlet.2008.09.027

Reference yield:

(R)-3-Amino-dihydro-furan-2,5-dione; hydrobromide + benzyl alcohol (100-51-6,185532-71-2) → D-aspartic acid benzyl ester (79337-40-9)

Guidance literature:

With triethylamine;

DOI:10.1021/ja00895a033

Reference yield: 77.0%

biotin pentafluorophenyl ester (120550-35-8) + D-aspartic acid benzyl ester (79337-40-9) → [D-(+)-biotinyl]-L-aspartate alpha-benzyl ester

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 2.25h;

upstream raw materials:

benzyl alcohol

(R)-2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

Downstream raw materials:

N-<(R)-3-(benzyloxy)tetradecanoyl>-(R)-aspartic acid α-benzyl ester

α-benzyl N-acetyl-D-aspartate

Refernces

• 1、 Liotta,Gibbs,Taylor,Benkovic,Benkovic. "Antibody-catalyzed rearrangement of a peptide bond: Mechanistic and kinetic investigations". . p. 4729 - 4741. Retrieved 2007/10/02.