Technology Process of diethyl 3-<2-(2-phenyl-1,3-dioxan-2-yl)ethyl>pentanedioate
There total 1 articles about diethyl 3-<2-(2-phenyl-1,3-dioxan-2-yl)ethyl>pentanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluorormethanesulfonic acid; triisobutylaluminum;
In
dichloromethane; toluene;
-78 deg C to r. t., 1 h;
DOI:10.1021/jo00043a038
- Guidance literature:
-
Multi-step reaction with 3 steps
1: porcine liver esterase (PLE, EC 3.3.1.1), phosphate puffer, 3.2M (NH4)2SO4, 1M NaOH / 72 h / Ambient temperature; pH 7-7.2
2: BH3 / tetrahydrofuran / 2.5 h
3: 1M aq. HCl / tetrahydrofuran
With
hydrogenchloride; ammonium sulfate; sodium hydroxide; phosphate puffer; porcine liver esterase (PLE, EC 3.3.1.1); borane;
In
tetrahydrofuran;
DOI:10.1021/jo00043a038
- Guidance literature:
-
Multi-step reaction with 7 steps
1: porcine liver esterase (PLE, EC 3.3.1.1), phosphate puffer, 3.2M (NH4)2SO4, 1M NaOH / 72 h / Ambient temperature; pH 7-7.2
2: BH3 / tetrahydrofuran / 2.5 h
3: 1M aq. HCl / tetrahydrofuran
4: tetrahydrofuran; H2O / 0.25 h / Heating
5: 11.7 g / dimethylsulfoxide / 2 h / 160 °C
6: 65 percent / NaH / dimethylsulfoxide / 1.5 h / 19 - 22 °C
7: CH2Cl2 / 1 h / 0 °C
With
hydrogenchloride; ammonium sulfate; sodium hydroxide; phosphate puffer; porcine liver esterase (PLE, EC 3.3.1.1); borane; sodium hydride;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo00043a038
